PRODUCTS  |  CELL & GENE THERAPY

Custom Projects

Engineer novel gene expression systems to
your specifications

SynGenSys’s unique data driven design approach allows rapid assessment of the transcriptional landscape of any target tissue, identification of features contributing to off target expression across all tissues, and parallel assessment of the expression requirements of the transgene.

Our design approach is applicable to gene expression across biopharmaceutical manufacturing, gene therapy, cell therapy and mRNA vaccine development. We build gene expression systems to meet the specific requirements of each application. Best fit, not one size fits all.

Our dedicated expertise and experience in delivering projects for major pharmaceutical and biotech clients ensures your confidence in delivery and outcomes to meet the needs of your project.

Virus Cells

Project delivery in defined stages. Progress, control, and visibility throughout

Stage 1
  • Customer requirements evaluation
  • Transcriptional landscape analysis
  • On/off signal interpretation for target and non-target tissues
  • Promoter strength assessment
  • Design for payload optimisation
  • IP landscape and freedom to operate evaluation
  • Sequence design recommendations
Stage 2
  • Down selection of promoter components
  • Promoter construct assembly
  • Optimisation and validation in relevant cell culture models
Stage 3
  • Demonstration of efficacy with target gene and delivery vector
  • In vivo systems/whole organism assessment
  • IP development support/prosecution
  • Preparation and support of documentation for customer regulatory requirements

Keeping you in control

Services may be selected in full, or as discrete elements to support individual requirements, development stage timing and resources. Intellectual property is secured as a matter of course throughout the project. Freedom to operate is assured through exclusive licence or assignment of IP to the customer to provide complete clarity and confidence from the outset.

Contact us about custom gene expression projects
CONTACT US
Virus Cells

Contact us

Find out more about how Syngensys technology can enhance your process development.

CONTACT US

Follow us

Sign up to receive regular notifications from the Syngensys team and follow our progress