PRODUCTS

Biomanufacturing

A bespoke solution optimised for results

Next generation biopharmaceuticals are not uniform. Optimising production needs more than a generic, one-size-fits-all vector system.

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Syngensys provides an off-the shelf, combinatorial library of promoters, ready to use and functionally validated to optimise production for single and multi-gene products.

Higher Titres
Faster Recovery
Greater Stability
Improved Qp
Reduced Cost
CHO.SET synthetic promoter library

Our unique knowledge-based promoter design platform

Syngensys unique knowledge-based promoter design platform allows tuning of promoter activity to meet the exacting requirements of complex manufacturing challenges, including difficult to express proteins and complex stoichiometry requirements

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Predictable promoter activity by design
Transcriptional hub design extends production capability

Greater stability and yield benefits

Engineering of the full Transcriptional Hub provides even greater stability and yield benefits. Synergistic relationships of proximal promoters employed to minimise interference and enhance transcriptional efficiency.

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Rapid

From promoter recommendations to lead and back-up expression vectors in 11 weeks.

De-risk

In-parallel testing of a wider combination of synthetic promoters for challenging proteins.

Ready-to-go

Promoter combinations and materials available off-the-shelf for use with well-behaved proteins.

On Silico Selection
Design minimal vector library vs. recombinant protein
Design minimal vector library vs. recombinant protein
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks
Vector Assembly
Assembly of promoters and GOIs
Assembly of promoters and GOIs
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks
Vector QC & Bulk-up
Sequence confirmation
Sequence confirmation
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks
Create Stable Pools
Transfect CHO host and expand pools
Transfect CHO host and expand pools
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks
Test Pools
Productivity in mini pools
Productivity in mini pools
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks
Analysis
Measure product concentration and analyse data
Measure product concentration and analyse data
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks
Deliver
Lead and back-ups
Lead and back-ups
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks
2 Wks
4 Wks
6 Wks
8 Wks
10 Wks
12 Wks

White paper

Services may be selected in full, or as discrete elements to support individual requirements, development stage timing and resources. Intellectual property is secured as a matter of course throughout the project. Freedom to operate is assured through exclusive licence or assignment of IP to the customer to provide complete clarity and confidence from the outset.

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Contact us

Find out more about how Syngensys technology can enhance your process development.

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