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About us

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Our Story

Follow our journey from idea to impact.

Our Team

Discover the faces behind our company's success.

Our Story

We are a growing company at the interface of cell and molecular biology, informatics and engineering. Our mission is to create innovative solutions for design and manufacture of next-generation medicines. SGS Technology harnesses years of research and development with both academic and bio industrial partners.
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See our publications below.

2014
2014
Brown AJ, Sweeney B, Mainwaring D, James DC (2014).
Synthetic promoters for CHO Cell Engineering. Biotechnology and Bioengineering 111: 1638-1647.
Brown AJ, Sweeney B, Mainwaring D, James DC (2014).
Synthetic promoters for CHO Cell Engineering. Biotechnology and Bioengineering 111: 1638-1647.
Publications
Green Arrow
2016
Brown AJ, James DC (2016).
Precision control of recombinant gene transcription for CHO cell synthetic biology. Biotechnology Advances. 34(5):492-503.
Brown AJ, James DC (2016).
Precision control of recombinant gene transcription for CHO cell synthetic biology. Biotechnology Advances. 34(5):492-503.
Publications
Green Arrow
2016
2017
2017
Brown AJ, James DC (2017).
Constructing strong cell type-specific promoters through informed design. Methods Mol. Biol. 1651:131-145.
Brown AJ, Gibson S, Hatton D, James DC (2017).
In silico design of context-responsive mammalian promoters with user-defined functionality. Nucleic Acids Research 45(18): 10906-10919.
Brown AJ, James DC (2017).
Constructing strong cell type-specific promoters through informed design. Methods Mol. Biol. 1651:131-145.
Brown AJ, Gibson S, Hatton D, James DC (2017).
In silico design of context-responsive mammalian promoters with user-defined functionality. Nucleic Acids Research 45(18): 10906-10919.
Publications
Green Arrow
2019
Brown AJ, Gibson S, Hatton D, Arnall C, Hames DC (2019).
Whole synthetic pathway engineering of recombinant protein production. Biotechnology and Bioengineering. 116(2): 375-387.
Johari Y, Brown AJ, Wright C, Alves C, Zhou Y, Estes S, James DC (2019).
CHO genome mining for synthetic promoter design. Journal of Biotechnology. 294:1-13.
Brown AJ, Gibson S, Hatton D, Arnall C, Hames DC (2019).
Whole synthetic pathway engineering of recombinant protein production. Biotechnology and Bioengineering. 116(2): 375-387.
Johari Y, Brown AJ, Wright C, Alves C, Zhou Y, Estes S, James DC (2019).
CHO genome mining for synthetic promoter design. Journal of Biotechnology. 294:1-13.
Publications
Green Arrow
2019
2020
2020
Johari YB, Jaffe SRP, Scarrot JM, Johnson AO, Mozzanino T, Pohle TH, Maisuria S, Bhauat-Commack A, Brown AJ, Tee KL, Jackson PJ, Wong TS, Dickman MJ, Sargur R, James DC (2020).
Production of trimeric SARS-CoV-2 Spike Protein by CHO cells for serological COVID-19 testing. Biotechnology and Bioengineering. 118: 1013-1021.
Johari YB, Jaffe SRP, Scarrot JM, Johnson AO, Mozzanino T, Pohle TH, Maisuria S, Bhauat-Commack A, Brown AJ, Tee KL, Jackson PJ, Wong TS, Dickman MJ, Sargur R, James DC (2020).
Production of trimeric SARS-CoV-2 Spike Protein by CHO cells for serological COVID-19 testing. Biotechnology and Bioengineering. 118: 1013-1021.
Publications
Green Arrow
2021
Johari Y, Brown AJ, Marcer A, James DC (2021).
Design of synthetic promoters for controlled expression of therapeutic genes in retinal pigment epithelial cells. Biotechnology and Bioengineering. 118: 2001-2015.
Patel YD, Brown AJ, Thompson B, Zhu J, Gibson S, Hatton D, James DC (2021).
Control of multigene expression stoichiometry in mammalian cells using synthetic promoters. ACS Synthetic Biology 10, 5, 1155-1165.
Founded
SynGenSys Founded 2021
Johari Y, Brown AJ, Marcer A, James DC (2021).
Design of synthetic promoters for controlled expression of therapeutic genes in retinal pigment epithelial cells. Biotechnology and Bioengineering. 118: 2001-2015.
Patel YD, Brown AJ, Thompson B, Zhu J, Gibson S, Hatton D, James DC (2021).
Control of multigene expression stoichiometry in mammalian cells using synthetic promoters. ACS Synthetic Biology 10, 5, 1155-1165.
Publications
Green Arrow
2021
2022
2022
Johnson AO, Fowler SB, Webster CI, Brown AJ, James DC (2022).
Bioinformatic design of dendritic cell specific promoters. ACS Synthetic Biology. 11(4): 1613-1626.
JohariYB, Scarrot JM, PohleTH, Liu P, Mayer A, Brown AJ, James DC (2022).
Engineering of the CMV promoter for controlled expression of recombinant genesin HEK293 cells. Biotechnology Journal. 17(8): e220006.
Johnson AO, Fowler SB, Webster CI, Brown AJ, James DC (2022).
Bioinformatic design of dendritic cell specific promoters. ACS Synthetic Biology. 11(4): 1613-1626.
JohariYB, Scarrot JM, PohleTH, Liu P, Mayer A, Brown AJ, James DC (2022).
Engineering of the CMV promoter for controlled expression of recombinant genesin HEK293 cells. Biotechnology Journal. 17(8): e220006.
Publications
Green Arrow
2023
Sou SN, Harris CL, Williams R, Kozub D, Zurio F, Patel YD, Muroni M, Dunn S, Daramola O, Brown AJ, James DC, Hatton D, Gibson S (2023).
CHO synthetic promoters improve expression and product quality of biotherapeutic proteins. Biotechnology Progress, in press. DOI: 10.1002/btpr.3348.
O’Neill P, Mistry RK, Brown AJ, James DC (2023).
Protein-Specific Signal Peptides for Mammalian Vector Engineering. ACS Synthetic Biology. doi: 10.1021/acssynbio.3c00157.
Sou SN, Harris CL, Williams R, Kozub D, Zurio F, Patel YD, Muroni M, Dunn S, Daramola O, Brown AJ, James DC, Hatton D, Gibson S (2023).
CHO synthetic promoters improve expression and product quality of biotherapeutic proteins. Biotechnology Progress, in press. DOI: 10.1002/btpr.3348.
O’Neill P, Mistry RK, Brown AJ, James DC (2023).
Protein-Specific Signal Peptides for Mammalian Vector Engineering. ACS Synthetic Biology. doi: 10.1021/acssynbio.3c00157.
Publications
Green Arrow
2023

Our Team

David James
Chief Scientific Officer
Adam Brown
Chief Technology Officer
Andrew Racher
Commercial Operations Director
Abayomi Johnson
Senior DNA Engineer
Renata Caikauskaite
Senior DNA Engineer
Cristina Alexandru-Crivac
Senior Bioinformatician
Francesca Taglini
Senior Cell Engineer
Molly Smith
Cell Engineer
Pamela O’Neill
Cell Engineer
Thilo Pohle
DNA Engineer
Clare Bowler
Administration Manager
Kate Fewkes
Senior Technician
Sam Saunders
Doctoral Candidate

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CONTACT US
SynGenSys Ltd.
5th Floor, 3 St. Paul’s Place,
129 Norfolk Street, Sheffield S1 2JE
United Kingdom​
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